Modalert Modafinil – The Gold Standard

Modalert is a stimulant drug designed for treatment of wakefulness disorders. Its a generic brand of modafinil produced by Sun Pharma used to treat clinical disorders associated with fatigue, sleep apnea, idiopathic hypersomnia,  obstructive sleep apnea, circadian rhythm sleep disorders (CRSD), narcolepsy/hypnolepsy, depersonalization disorders, impaired cognition, ADHD and other symptoms.

Modalert (Provigil) smart drug - ModNerd

The smart drug everyone is talking about

It has quickly become the gold standard for modafinil in the UK since Cephalon’s patent for Provigil modafinil expired in 2001.

Because of it’s extremely low price compared to Provigil Modalert has fiercely dominated the market. The cost of Modalert (generic modafinil) in the United Kingdom is five times lower than Provigil (brand modafinil). With cost-effectiveness like this its no wonder that doctors are now heavily recommending it to their patients.

 

Uses of Modalert

Approved Uses

Narcolepsy

Narcolepsy is a rare, long-term neurological disorder effecting the control of sleep and wakefulness causing a person to suddenly and uncontrollably fall asleep during the day. Modafinil was approved by the U.S Food and Drug Administration (FDA) for treatment of narcolepsy in 1998. In narcoleptic patients modafinil is proven effective in the treatment of excessive sleepiness but not cataplexy.

Shift Work Sleep Disorder (SWD)

Shift work sleep disorder is a disorder of the circadian rhythm. It affects people who regularly work at night and reschedule work shifts in-place of regular sleeping patterns. It is characterized by insomnia and excessive sleepiness. Modafinil is FDA approved for the treatment of SWD. It does not cure the underlying sleep problem instead dealing with symptoms of sleepiness. Modafinil is an effective treatment for excessive sleepiness associated with SWD significantly improving functioning and quality of life in patients.

Obstructive Sleep Apnea (OSA) and Hypopnea

Obstructive sleep apnea is the most common form of sleep apnea, it is caused by throat muscles relaxing and obstructing the airway during sleep. Its a disorder in which breathing repeatedly stops and starts during sleep. In 2003 the FDA approved Modafinil for the treatment of obstructive sleep apnea. Modafinil is used to treat the excessive sleepiness but not the obstruction causing OSA.

Hypopnea is a sleep disorder similar to sleep apnea. It consists of events of shallow breathing or a lowered respiratory rate. The causes and mechanisms differ from sleep apnea but the net result is the same: interrupted sleep resulting in excessive daytime sleepiness. Modafinil is FDA approved for treating the symptoms of Hypopnea.

International Considerations

Medicinal Products for Human Use (CHMP), a branch of The European Medicines agency in 2007 reviewed the safety and effectiveness of modafinil. As a result the organization revised Article 31 of Directive 2001/83/EC to restrict use of Modafinil to treatment of narcolepsy. The reason for this restriction is cited as potential for developing a skin rash and that benefits do not outweigh the risks. After re-examination, the Committee upheld these recommendations on 18 November 2010.

Unapproved Uses

Cognitive enhancement

Modafinil is usually prescribed to treat narcolepsy and has been used in the past by the US Air Force to keep helicopter pilots alert during 48 hour flights. But in recent years students have used the drug to help them concentrate on their work in the build-up to exams and deadlines.

Students all over the UK are flocking to Modafinil to increase their studying efforts. Modafinil has been used by one in five students in the UK as a study drug. Study drugs are taken for the purpose of increasing grades and to help in learning. Modafinil reports to increase stamina, concentration and memory making it a particularly potent revision or cramming tool. With a half-life of 15 hours the drug can dramatically enhance concentration for long periods of time, students with extremely demanding lifestyles may also find themselves up late partying, leaving them tired during the day and inefficient at studying. Modafinil seems to solve this conundrum, as evident by abundant marketing associating modafinil as an essential tool in a students arsenal.

ADHD

Preliminary studies indicate that Modafinil is a viable alternative to conventual stimulants used to treat adults with ADHD. Modafinil appears to be an effective treatment and has fewer addictive properties than the traditional treatments of amphetamines. Despite modafinil’s lack of addictive properties making it ideal in treatment for children it has not received approval for treatment of ADHD. A primary reason that modafinil is not approved by the FDA for treatment of ADHD is because of it’s unknown and ambiguous association with Stevens-Johnson syndrome. In a study out of 933 children 2 developed a serious skin rash.

Depression

A recent study from the Universities of Cambridge and King’s College London has revealed that taking modafinil in conjunction with antidepressants reduces the severity of depression more effectively than taking antidepressants alone. Modafinil interacts with numerous neurotransmitter systems potentially explaining why combining it with antidepressants has beneficial and unforseen side effects. Their analysis revealed modafinil as a potent reducer of the severity of depression and key in amplifying remission rates. The study noted the added benefits of reduced fatigue and sleepiness and explained that the side effects of the treatment were on the same level as that of a placebo.

Multiple Sclerosis (MS)

Multiple Sclerosis is an immune related neurodegenerative disease effecting the integrity of the Central Nervous system. Symptoms involve massive inefficiencies in transmitting action potentials down neurones eventually leading paralysis and loss of motor control. In 2000 Cephalon released a controlled study to evaluate modafinil as a potential treatment for MS-related fatigue. The data of the study implicates modafinil as significantly improving general tiredness without any rejections or notable complications in patents with MS.

Dosage

Condition Drug Form Amount Indications
Narcolepsy Modalert (modafinil) Tablet 200mg-400mg IF your dose is 200mg take orally once a day as a single dose in the morning.
IF your dose is 400mg take orally twice a day, one dose in the morning and one at mid-day.
Shift Work Sleep Disorder Modalert (modafinil) Tablet 200mg Taken orally 1 hour prior to the start of a work shift.
Obstructive Sleep Apnea (OSA) Modalert (modafinil) Tablet 200mg Taken orally once a day in the morning.
Hypopnea Modalert (modafinil) Tablet 200mg Taken orally once a day in the morning.
Idiopathic hypersomnia Modalert (modafinil) Tablet 200mg-400mg IF your dose is 200mg take orally once a dayas a single dose in the morning.
IF your dose is 400mg take orally twice a day, one dose in the morning and one at mid-day.

 

 Considerations

  • In patients with serious liver impairment, the dose of Modalert should be reduced to one-half of that recommended for patients with normal liver function
  • When treating elderly patients start off at 100mg doses and monitor effects, then increase to a full dose. This is because aging can cause both renal and hepatic inefficiencies.
  • In patients with serious renal impairment modafinil should not be taken at all
  • It is not advised to administer this medication to children under the age of 12
  • Modalert has a haf life of 15 hours, this is quite long, thus it is advised not to take Modalert modafinil in the evening

Side effects

Do not continue to use Modalert modafinil and alert a medical professional immediately if you have any of these serious side effects:

  • red skin rash, fever, irritated throat, vomiting with blistering of the skin, peeling skin, headache;
  • Pain in your chest,  heart palpitations;
  • delusional thinking, hallucinations, strange behavior and thoughts;
  • pain, pins and needles, numbness, physical fatigue;
  • depression, extreme anxiety, aggression;
  • sores or white spots on your lips or inside your mouth; or
  • abnormal bruising and bleeding.

Less serious side effects may include:

  • dizziness, headache;
  • nausea, diarrhea;
  • feeling nervous or irritated;
  • dry mouth; or
  • insomnia.

This list of side effects is not exhaustive and you may experience additional side effects. Contact a medical professional for help regarding side effects. You can report side effects to the FDA at this number: 1-800-FDA-1088.

Buying Modafinil Online

Modafinil can be brought online from high quality vendors such as modafinilcat.com and modup.net with or without prescription. Please do prior research about the laws of your country to see if you are able to import modafinil in your current situation